Assessing genome-wide statistical significance for large p small n problems.
نویسندگان
چکیده
Assessing genome-wide statistical significance is an important issue in genetic studies. We describe a new resampling approach for determining the appropriate thresholds for statistical significance. Our simulation results demonstrate that the proposed approach accurately controls the genome-wide type I error rate even under the large p small n situations.
منابع مشابه
On Assessing Genome-Wide Statistical Significance for Large p Small n Problems
Assessing genome-wide statistical significance is an important issue in genetic studies. We describe a new resampling approach for determining the appropriate thresholds for statistical significance. Our simulation results demonstrate that the proposed approach accurately controls the genome-wide type I error rate even under the large p small n situations.
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ورودعنوان ژورنال:
- Genetics
دوره 194 3 شماره
صفحات -
تاریخ انتشار 2013